Laminin G-like domains: dystroglycan-specific lectins
نویسندگان
چکیده
منابع مشابه
Basal lamina strengthens cell membrane integrity via the laminin G domain-binding motif of alpha-dystroglycan.
Skeletal muscle basal lamina is linked to the sarcolemma through transmembrane receptors, including integrins and dystroglycan. The function of dystroglycan relies critically on posttranslational glycosylation, a common target shared by a genetically heterogeneous group of muscular dystrophies characterized by alpha-dystroglycan hypoglycosylation. Here we show that both dystroglycan and integri...
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Dystrophin, a gene product that is mutated in individuals with Duchenne muscular dystrophy, is tethered to the extracellular matrix via membrane-associated multimolecular complexes. In striated muscle cells this complex contains two glycoprotein subcomplexes, the sarcoglycan (SG) and dystroglycan (DG) complexes. Disruption of these large transmembrane complexes has been shown to result in muscl...
متن کاملLaminin - 1 globular domains 3 and 4 induce heterotrimeric G protein binding to - syntrophin ’ s PDZ domain and alter intracellular Ca 2 in muscle
Zhou, Yan Wen, Shilpa A. Oak, Susan E. Senogles, and Harry W. Jarrett. Laminin1 globular domains 3 and 4 induce heterotrimeric G protein binding to -syntrophin’s PDZ domain and alter intracellular Ca in muscle. Am J Physiol Cell Physiol 288: C377– C388, 2005. First published September 22, 2004; doi:10.1152/ajpcell. 00279.2004.— -Syntrophin is a component of the dystrophin glycoprotein complex (...
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α-dystroglycan is a highly O-glycosylated extracellular matrix receptor that is required for anchoring of the basement membrane to the cell surface and for the entry of Old World arenaviruses into cells. Like-acetylglucosaminyltransferase (LARGE) is a key molecule that binds to the N-terminal domain of α-dystroglycan and attaches ligand-binding moieties to phosphorylated O-mannose on α-dystrogl...
متن کاملIMGT standardization and analysis of V-LIKE-, C-LIKE- and G-LIKE-DOMAINs
IMGT, the international ImMunoGeneTics information system (http://imgt.cines.fr) [1], was created in 1989 at Montpellier. IMGT specializes in immunoglobulins (IG), T cell receptors (TR) and major histocompatibility complex (MHC) and related proteins of the immune system (RPI) from human and other vertebrate species. Three structural and functional domains have been identified for the IG and TR...
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ژورنال
عنوان ژورنال: Current Opinion in Structural Biology
سال: 2019
ISSN: 0959-440X
DOI: 10.1016/j.sbi.2018.11.007